Sculptris Pro
Ignore the constraints of polygon distribution and simply – sculpt! Sculptris Pro will dynamically add (tesselate) and remove (decimate) polygons wherever and whenever needed. It does this during your brush stroke in a real-time process called Tessimation. This frees you to focus entirely on the look you’re trying to achieve.
Dynamesh
DynaMesh is a perfect solution for free-form sculpting because it removes all need for focusing on topological constraints. Where Sculptris Pro dynamically adjusts the triangles in your mesh as you sculpt, DynaMesh redistributes the model’s polygons as quads on command.


ZModeler
While ZBrush is best known for organic sculpting, its hard surface capabilities should not be underestimated. The ZModeler system is designed specifically for low poly modeling with easily accessed and highly intuitive controls for creating holes, adding edge loops, extruding polygons and much more.
ZBrush Artist :: Joseph Drust
Live Boolean
Many models are really nothing more than a set of shapes that combine to form a more detailed shape. Live Boolean takes this concept and runs with it, providing a way to easily add models together, subtract one from another and more. What makes the system in ZBrush unique is that this operation happens in real-time, letting you see exactly what you’re going to get before committing to the actual merger. This provides both exceptional ease of use and unprecedented control.


ZSpheres
If you’ve ever added clay to a wire armature then you know exactly how ZSpheres work. Draw a simple skeleton/stick figure and ZBrush will then flesh it out with actual topology.
Mannequins
An evolution to ZSpheres is the Mannequin system. With a wide variety of both humanoid and animal figures in the library, Mannequins are an easy starting point as you explore the scene that you wish to create, before even beginning modeling.

ZRemesher
As you have read through the features listed above you may have found yourself wondering about the kind of topology that is created. The beauty of ZBrush is that you don’t need to worry about that! Feel free to explore and just let your imagination take you where it wants with the knowledge that once you have your design ZBrush can nearly instantly convert its polygons into a usable base mesh with clean edge loops and polygon flow.